The effect of eight weeks of aerobic exercise and coriander seed extract on oxidative stress and cellular energy indices of heart tissue in male rats poisoned with hydrogen peroxide

Introduction: The aim of this research was to investigate the effect of eight weeks of aerobic training and coriander seed extract with two doses of 5 and 10 mg on oxidative stress markers and cardiac muscle ATP levels of rats poisoned with hydrogen peroxide. Methods: 42 healthy adult male rats were randomly divided into 7 groups. During one week, the groups were poisoned intraperitoneally by receiving 100 mg/kg of hydrogen peroxide. In the following, the target groups were subjected to intervention on the treadmill for eight weeks (5 sessions of 60 minutes per week) with doses of 5 and 10 mg per kilogram of coriander seed extract. At the end, the concentration of ATP, MDA and PAB indicators was measured using ELISA method. Results: The results of analysis of variance test showed the decreasing effect of aerobic exercise on MDA and PAB values (P<0.05), while it had no significant effect on ATP concentration (P>0.05). On the other hand, consumption of two doses of coriander seed extract had no significant effect on the prooxidant-antioxidant balance (P>0.05), while their consumption caused a significant increase in ATP concentration (P<0.05). Conclusion: Despite the fact that eight weeks of aerobic exercise is considered a suitable solution for modulating the changes in oxidative indices caused by hydrogen peroxide poisoning, this intervention does not have a significant effect on the amount of myocardial cellular energy. On the other hand, the effects of coriander seed extract are probably dose-dependent in some cases.